Webdesigned to develop and evaluate the chitosan-graft-polyethylenimine (CP)/DNA nanoparticles as novel non-viral gene vectors for gene therapy of osteoarthritis.
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WebChitosan is a fibrous compound derived from chitin, which is the second most abundant natural polysaccharide and is produced by crustaceans, including crabs, shrimps, and lobsters. Chitosan has all of the important medicinal properties, including biocompatibility, biodegradability, and hydrophilicity, and it is relatively nontoxic and cationic in nature. … WebJan 28, 2024 · A The optical images of the gelation progress. The mixture of N-chitosan and ADH presented in the sol state at room temperature, and it experienced sol-gel …
WebApr 10, 2024 · Novel hyaluronic acid–chitosan nanoparticles as non-viral gene delivery vectors targeting osteoarthritis. International Journal of Pharmaceutics, 420 (2) (2011) ... Combining hyaluronic acid with chitosan enhances gene delivery. Journal of Nanomaterials (2014), 10.1155/2014/246347. 2014. Article 152. Google Scholar. WebIntroduction. Cartilage injury, a common clinical problem, can be caused by trauma, 1 osteoarthritis, 2 rheumatoid arthritis, 3 and exfoliative chondritis. 4 Articular cartilage is …
WebConventional treatments for osteoarthritis (OA), including drug delivery and tissue engineering approaches, could not offer a high yield of cartilage repair due to the compact and exclusive structure of cartilage. Targeted and high-efficiency delivery of gene sequences is necessary to rebalance the lost homeostatic properties of the cartilage ... WebChitosan–pDNA nanoparticle characteristics determine the transfection efficacy of gene delivery to human mesenchymal stem cells E Malakooty Poor, M Baghaban Eslaminejad, N Gheibi, F Bagheri, ... Artificial cells, nanomedicine, and biotechnology 42 (6), 376-384 , 2014
WebThingreila Muinao, ...Mintu Pal, in Polysaccharide Carriers for Drug Delivery, 2024. 15.4.2.9 Chondroitin sulfate. Chondroitin sulfate is a natural water soluble polymer comprising of repeating disaccharide units of d-glucuronic acid and N-acetylgalactosamine, sulfated at either 4- or 6-positions.While cross-linked chondroitin sulfates may show less hydrophilic …
WebThere are two main approaches for gene delivery using viral and non-viral gene transfer systems for treating articular cartilage defects in OA, or following joint trauma. The first is … shark cannonWebJan 28, 2024 · Methods In this study, an injectable and self-healing hydrogel was synthesized by in situ crosslinking of N -carboxyethyl chitosan ( N -chitosan), adipic acid dihydrazide (ADH), and hyaluronic... shark cannabis strainWebDec 1, 2016 · Efficacy of the combination of CM-cordycepin and HAMA hydrogel as a treatment for OA. Safranin-O staining of cartilage samples 4 weeks (A) and 8 weeks (B) after OA induction. shark cannonballsWebMar 3, 2006 · Next, chitosan–DNA nanoparticles containing IL-1Ra or IL-10 gene were injected directly into the knee joint cavities of osteoarthritis rabbits to clarify the in vivo … poptown.clubWebNov 28, 2011 · Gene therapy is a promising new treatment strategy for common joint-disorders such as osteoarthritis. The development of safe, effective, targeted non-viral … poptown lofts macon gaWebApr 12, 2024 · Chitosan is a naturally occurring polysaccharide that is derived from chitin, a major component of the exoskeletons of crustaceans such as shrimp, crab, and lobster. It has been gaining attention in the field of biotechnology and biomedicine due to its unique properties and potential applications. Chitosan is a linear polysaccharide that consists of … poptown hsvWebJun 1, 2024 · Modifying chitosan with target ligands is a promising method for the targeted delivery of genes by delivery systems based on chitosan. Proteins, peptides, aptamers, carbohydrates, and small molecules are common ligands used to realize target delivery in gene vectors based on chitosan. poptown popsicles