Cyclic pifithrin-a
WebPifithrin-α (PFT-α; Item No. 13326) is a reversible inhibitor of p53-dependent transcription and apoptosis. 1 Cyclic PFT-α, also known as PFT-β, is a stable analog of PFT-α, formed by the condensation of pifithrin-α in solution. 2 It inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC 50 = 23, 77, and 103 μM, respectively). 2,3 At doses … WebCyclic pifithrin-alpha sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis Authors Valentina Zuco 1 , Franco Zunino Affiliation 1 Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy. PMID: 18516295 PMCID: PMC2386543 DOI: 10.1593/neo.08262 …
Cyclic pifithrin-a
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WebCyclic pifithrin-alpha-p-nitro, transcriptional p53 inhibitor(PFT-α) 是一种 p53 的灭活剂,可阻断 p53 依赖性转录激活和细胞凋亡。 Cyclic PFT-α 是 PFT-α 的稳定类似物。 p-nitro-Cyclic PFT-α 是一种可渗透细胞的环状 PFT-α。 在保护暴露于依托泊苷 (ED50 = 30 nM) 的皮质神经元方面,它比 ... WebJul 1, 2008 · In this study, we used cyclic pifithrin-α, a transcriptional inhibitor of p53, to further investigate the relevance of p53 function in the response of tumor cells to …
WebCyclic Pifithrin-alpha Hydrobromide 98.0 %, TCI America Fisher Scientific Fisher Scientific Fisher Healthcare Fisher Science Education Sign Up for Email Help & Support … WebCyclic pifithrin-alpha sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis Authors Valentina Zuco 1 , Franco Zunino Affiliation 1 Department of …
WebJan 23, 2024 · Interestingly, pretreatment with a p53 inhibitor (cyclic pifithrin-α) did not prevent RCX-induced apoptosis, indicating the activation of ERK1/2-mediated apoptosis in HepG2 cells by the p53 ... WebCyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine …
WebJul 1, 2008 · (PDF) Cyclic Pifithrin-α Sensitizes Wild Type p53 Tumor Cells to Antimicrotubule Agent–Induced Apoptosis 1 Cyclic Pifithrin-α Sensitizes Wild Type p53 Tumor Cells to Antimicrotubule...
WebJan 11, 2024 · Select the department you want to search in ... mysql create database testWebJul 17, 2024 · Cell-based assays in multiwell plates are widely used for radiosensitivity and chemosensitivity assessment with different mammalian cell types. Despite their relative ease of performance, such assays lack specificity as they do not distinguish between the cytostatic (reversible/sustained growth arrest) and cytotoxic (loss of viability) effects of … the spike tier listWebPifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in … mysql create hash indexWebCyclic Pifithrin-α hydrobromide has been used as p53 inhibitor to study its role in cigarette smoke−induced apoptosis of pulmonary endothelial cells. [ 1] Packaging 5, 10 mg in … mysql create index using hashWebApr 1, 2005 · Cyclicpifithrin-α, a well-characterized small-molecule inhibitor of p53-dependent transactivation of p53-responsive genes, was used as positive control (33). Together, these results suggest that... mysql create index on json columnWebCyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α a small molecule inhibitor of p53. It reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis, with less cytotoxicity than the parent compound. Potent STAT6 transcriptional inhibitor. mysql create function ifWebCyclic Pifithrin-alpha is a reversible and cell-permeable inhibitor of p53, which plays a crucial role in apoptosis, angiogenesis, and genomic stability. The cyclic form is the more stable and less cytotoxic version of the molecule. It is reported to be capable of increasing the efficiency of inducing pluripotent stem cells. the spike volleyball apk