WebJun 6, 2024 · The field of immunometabolism has demonstrated that metabolites can lead double lives as immunomodulators. Itaconate is perhaps the best example of such a moonlighting molecule, and has been shown to have multiple anti-inflammatory effects in macrophages. Itaconate is significantly upregulated under inflammatory conditions, and … WebBiogenic amines are decarboxylation products of amino acids and are formed during fermentation (e.g., cheese ripening and wine fermentation) and decomposition of protein, …
Impaired Metabolic Flexibility in a Mouse Model Of Leigh …
WebItaconate-derived protein dicarboxypropylation provides a robust measure of the cellular capacity to increase immunometabolism, and we observe that this is recognized by an in … WebJul 20, 2024 · These NLRP3 modifications include SUMOylation [163,164,165], nitrosylation [166,167,168], alkylation [169,170], acetylation , and dicarboxypropylation, which is a rare modification mediated by 4-octyl itaconate, a derivative of immunomodulatory metabolite itaconate [172,173]. Collectively, phosphorylation and various PTMs are critical ... danielle carruthers
Coupling Krebs cycle metabolites to signalling in immunity
WebApr 1, 2024 · In addition, 4-octyl itaconate (OI), an itaconate derivative, can modulate NLRP3 activation by inhibiting the interaction of NLRP3 with NEK7 through dicarboxypropylation of C548 on NLRP3 [68]. By contrast, another study suggested that itaconate confers tolerance to NLRP3 activation by acting downstream of ASC speck … WebMay 12, 2024 · Mechanistically, Itaconate due to its electrophilicity structure of containing α, β-unsaturated carboxylic acid could make it form a modification of 2,3-dicarboxypropyl … WebOct 24, 2012 · These NLRP3 modifications include SUMOylation [163][164][165], nitrosylation [166][167] [168], alkylation [169,170], acetylation [171], and dicarboxypropylation, which is a rare modification ... danielle catania\u0027s brother robert catania