Irf4 flow
WebSep 22, 2013 · IRF4 regulated the expression of key molecules required for the aerobic … WebApr 9, 2024 · Flow cytometry was used to identify the proportion of pro-inflammatory CD86 + CD206-and HL associated anti-inflammatory CD163 + CD206 ... (weak expression), and IRF4/MUM1. Surface B-cell markers such as CD20 and CD79a are often negative, although CD20 may be more variably expressed in practice due to improved antigen retrieval …
Irf4 flow
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WebJan 1, 2015 · Anaplastic large cell lymphoma (ALCL) is a distinct entity of T-cell lymphoma that can be divided into 2 subtypes based on the presence of translocations involving the ALK gene (ALK + and ALK − ALCL). The interferon regulatory factor 4 (IRF4) is known to be highly expressed in both ALK + and ALK − ALCLs. However, the role of IRF4 in the …
WebAntibodies that detect IRF4 can be used in several scientific applications, including … WebIRF4 is lymphocyte specific and negatively regulates toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t (6;14) (p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found.
WebNov 26, 2024 · IRF4 Deletion in Plasma Cells Leads to Apoptosis. To investigate the … WebOct 7, 2011 · Irf4-/- mice, however, display no obvious abnormality in myeloid cell development, presumably because IRF4 is expressed at a much lower level than IRF8 in granulocyte-macrophage progenitors. ... Flow cytometry analysis demonstrated that these morphological changes accompanied the expression of CD11b, F4/80 and M-CSF …
WebMay 15, 2014 · Loss of interferon regulatory factor 4 (IRF4) specifically in the myeloid cells evoked a constitutive M1 polarization in the adipose tissue, suggesting that IRF4 is a negative regulator of inflammation in diet-induced obesity, in part through regulation of macrophage polarization ( 14 ).
WebMay 27, 2024 · IRF4 protein quantification may provide a valuable prognostic tool to predict disease severity and sensitivity to IRF4-targeted therapies. This flow-cytometry-based procedure could also be rapidly translated into a clinically compatible assay. For complete details on the use and execution of this protocol, please refer to Mondala et al. (2024). high milk priceWebDec 3, 2024 · AMI results from a sudden interruption of blood flow in the coronary artery, causing an ischaemic and hypoxic microenvironment in myocardial tissue and leading to cardiomyocyte necrosis and impaired heart function ... The mRNA level of Irf4 was also significantly decreased in sorted macrophages from Adk MAC-KO hearts compared to … high milk chocolateWebAug 6, 2024 · Notably, an IRF4 rearrangement with a gain of the IRF4 gene was detected (panel I; FISH analysis with break-apart probes showed split red/green signals in 85% to 90% of tumor nuclei with a gain of the IRF4 gene, with an average of 3.5 and 3.4 red and green signals, respectively, per neoplastic cell; yellow arrows, normal alleles; red and green … how many 16 oz bottles of water is 2.7 litersWebDec 31, 2024 · Flow cytometry data showed that IRF4 CKO had significantly more leukocytes, including total peripheral myeloid cells (pMyeloid), monocytes, and neutrophils, infiltrating into the stroke brain compared to the control group ( Fig. 5 A – D ). how many 16 seeds have beaten 1 seedsWebTel +86 13607141618. Email [email protected]. Background: Therapeutic hypothermia (TH) has been proven to be protective in ischemic stroke (IS) due to its anti-inflammatory capacity. Recently, the interferon regulatory factor 4 (IRF4) has been characterized as a central regulator of neuroinflammation in IS. how many 16 oz bottles of water per dayWebDescription: The monoclonal antibody 3E4 reacts with human and mouse interferon … how many 16 oz bottles equal a gallonWebMay 14, 2015 · We previously discovered a recurrent translocation in PTCL, t(6;14)(p25.3;q11.2), that juxtaposes the interferon regulatory factor-4 (IRF4) and T-cell receptor-α (TRA) genes and is associated with increased IRF4 expression. 6 Because TRA translocation partners typically function as oncogenes in T-cell malignancies, we … high military positions